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1

Base editing: advances and therapeutic opportunities

Porto, Elizabeth M., Komor, Alexis C., Slaymaker, Ian M., Yeo, Gene W.

Journal:

Nature Reviews Drug Discovery

Year:

2020

File:

PDF, 2.03 MB

2020

2

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

Komor, Alexis C., Badran, Ahmed H., Liu, David R.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.29 MB

english, 2016

3

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Kim, Y Bill, Komor, Alexis C, Levy, Jonathan M, Packer, Michael S, Zhao, Kevin T, Liu, David R

Journal:

Nature Biotechnology

Year:

2017

Language:

english

File:

PDF, 409 KB

english, 2017

4

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

Komor, Alexis C., Badran, Ahmed H., Liu, David R.

Journal:

Year:

2017

Language:

english

File:

PDF, 60 KB

english, 2017

5

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Gaudelli, Nicole M., Komor, Alexis C., Rees, Holly A., Packer, Michael S., Badran, Ahmed H., Bryson, David I., Liu, David R.

Journal:

Year:

2017

Language:

english

File:

PDF, 23.37 MB

english, 2017

6

Selective Cytotoxicity of Rhodium Metalloinsertors in Mismatch Repair-Deficient Cells

Ernst, Russell J., Komor, Alexis C., Barton, Jacqueline K.

Journal:

Year:

2011

Language:

english

File:

PDF, 464 KB

english, 2011

7

The path for metal complexes to a DNA target

Komor, Alexis C., Barton, Jacqueline K.

Journal:

Chemical Communications

Year:

2013

Language:

english

File:

PDF, 3.07 MB

english, 2013

8

Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization

Komor, Alexis C., Schneider, Curtis J., Weidmann, Alyson G., Barton, Jacqueline K.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 2.28 MB

english, 2012

9

Targeted Chemotherapy with Metal Complexes

Weidmann, Alyson G., Komor, Alexis C., Barton, Jacqueline K.

Journal:

Comments on Inorganic Chemistry

Year:

2014

Language:

english

File:

PDF, 472 KB

english, 2014

10

An Unusual Ligand Coordination Gives Rise to a New Family of Rhodium Metalloinsertors with Improved Selectivity and Potency

Komor, Alexis C., Barton, Jacqueline K.

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 3.84 MB

english, 2014

11

Correction to Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization

Komor, Alexis C., Schneider, Curtis J., Weidmann, Alyson G., Barton, Jacqueline K.

Journal:

Journal of the American Chemical Society

Year:

2013

File:

PDF, 130 KB

2013

12

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Komor, Alexis C., Kim, Yongjoo B., Packer, Michael S., Zuris, John A., Liu, David R.

Journal:

Year:

2016

Language:

english

File:

PDF, 6.23 MB

english, 2016

13

ChemInform Abstract: The Path for Metal Complexes to a DNA Target

Komor, Alexis C., Barton, Jacqueline K.

Journal:

Year:

2013

File:

PDF, 18 KB

2013

14

Editing the Genome Without Double-Stranded DNA Breaks

Komor, Alexis C, Badran, Ahmed H, Liu, David R

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 918 KB

english, 2017

15

Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Gaudelli, Nicole M., Komor, Alexis C., Rees, Holly A., Packer, Michael S., Badran, Ahmed H., Bryson, David I., Liu, David R.

Journal:

Year:

2018

File:

PDF, 371 KB

2018

16

Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools

Fox, Keolu, Rallapalli, Kartik Lakshmi, Komor, Alexis C.

Journal:

Year:

2020

Language:

english

File:

PDF, 1.06 MB

english, 2020

17

A Hydrogen-Bond Facilitated Cycle for Oxygen Reduction by an Acid- and Base-Compatible Iron Platform

Soo, Han Sen, Komor, Alexis C., Iavarone, Anthony T., Chang, Christopher J.

Journal:

Inorganic Chemistry

Year:

2009

Language:

english

File:

PDF, 2.87 MB

english, 2009

18

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Rees, Holly A., Komor, Alexis C., Yeh, Wei-Hsi, Caetano-Lopes, Joana, Warman, Matthew, Edge, Albert S. B., Liu, David R.

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 849 KB

english, 2017

19

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Komor, Alexis C., Zhao, Kevin T., Packer, Michael S., Gaudelli, Nicole M., Waterbury, Amanda L., Koblan, Luke W., Kim, Y. Bill, Badran, Ahmed H., Liu, David R.

Journal:

Science Advances

Year:

2017

Language:

english

File:

PDF, 2.60 MB

english, 2017

20

Genome, Epigenome, and Transcriptome Editing via the Chemical Modification of Nucleobases in Living Cells

Ranzau, Brodie L., Komor, Alexis

Journal:

Year:

2018

Language:

english

File:

PDF, 353 KB

english, 2018

21

Rationalizing the Effect of Mutations on the Editing Efficiency of Adenine Base Editors

Rallapalli, Kartik Lakshmi, Paesani, Francesco, Komor, Alexis

Journal:

Biophysical Journal

Year:

2020

Language:

english

File:

PDF, 40 KB

english, 2020

22

Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors

Rallapalli, Kartik L., Komor, Alexis C., Paesani, Francesco

Journal:

Science Advances

Year:

2020

File:

PDF, 3.79 MB

2020

23

Base Editing in Human Cells to Produce SingleâNucleotideâVariant Clonal Cell Lines

Vasquez, Carlos A., Cowan, Quinn T., Komor, Alexis C.

Journal:

Current Protocols in Molecular Biology

Year:

2020

File:

PDF, 8.34 MB

2020